Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation
Figure 4
Network analysis of directly related genes which are upregulated and downregulated in HCC-R tumor tissues compared with HCC-NR tumor tissues. (a) The upregulated network includes genes dominated by regulators of cell cycle progression, cell growth and proliferation, DNA recombination, and cell-to-cell signaling genes. These are represented as respective shapes based on functional property in HCC-R tumor tissues. (b) The downregulated network includes genes reflecting the concurrent downregulation of genes related to innate immune response, cell-to-cell signaling, cell morphology, and cellular metabolism genes. These are represented as respective shapes based on their functional properties in HCC-R tumor tissues. The gray outlined nodules without expression are linker genes that are not altered in HCC-R but are statistically enriched for interaction with the altered genes.
