Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany

Table 1

Summary of donor characteristics and transplant variables used in univariate analyses of graft-survival after isolated kidney transplantation (KTX). For interval-scaled parameters absolute numbers, median, interquartile range, risk ratio (with 95% confidence interval), and values (Cox regression) are shown. For nominal and categorical parameters absolute numbers, proportions, the percentage of graft-failures, and values (log-rank test) are shown. All donor characteristics and transplant variables investigated are shown in supplementary Table e1.

Donor characteristics and basic donor data	Unit of analysis or factor level	at risk	(%)	Median	Interquartile range	Graft-failure (%) or hazard ratio [95% CI]	value
Age	Year	4392		56	45–67	1.027 [1.021–1.033]	<0.001
Gender	Female	2085	(47.3)			14.0%	0.490
	Male	2326	(52.7)			13.5%
Weight	kg	4411		80.0	70.0–90.0	0.998 [0.993–1.002]	0.320
Size	cm	4411		172.0	165.0–180.0	0.984 [0.977–0.992]	<0.001
Stay in intensive care unit	day	774		4.0	2.0–8.0	0.987 [0.970–1.005]	0.148
Cause of death	Cerebral hypoxia	557	(12.6)			11.7%	0.003
	CVA (bleeding)	2516	(57.0)			14.9%
	Ischemic stroke	497	(11.3)			14.7%
	Other	78	(1.8)			1.3%
	Trauma	763	(17.3)			11.9%
Cardiac resuscitation [10]	None	3876	(87.8)			14.0%	0.094
	Any	535	(12.1)			11.8%
Procurement and allocation
Time of death until cross clamp
(i) With procurement of thoracic organs	Hour	1900	(43.1)	12.3	10.0–15.9	0.988 [0.964–1.011]	0.306
(ii) Without procurement of thoracic organs	Hour	2511	(56.9)	8.8	6.6–11.4	0.985 [0.967–1.003]	0.111
Ischemia time	Minute	4411		741.0	544.0–946.0	1.000 [1.000–1.000]	0.544
Preservation solution	HTK	3804	(86.2)			13.7%	0.217
	UW	597	(13.5)			13.9%
	Other	10	(0.2)			30.0%
Graft-quality at recovery	Good	3965	(90.7)			12.8%	<0.001
	Poor or medium	405	(9.3)			23.7%
Medication (at ET report)
Catecholamines; (actual)	No	1138	(25.8)			16.2%	0.016
	Yes	3273	(74.2)			12.9%
Catecholamines; within last 24 hours	No	765	(17.3)			16.2%	0.035
	Yes	3646	(82.7)			13.2%
Additional diagnosis
History of arterial hypertension	Not reported	2568	(58.2)			12.3%	0.001
	Reported	1843	(41.8)			15.7%
History of diabetes	Not reported	4240	(96.1)			13.6%	0.097
	Reported	171	(3.9)			17.5%
History of coronary heart disease	Not reported	3584	(81.3)			13.3%	0.027
	Reported	827	(18.7)			15.7%
History of smoking	Not reported	3177	(72.0)			14.3%	0.181
	Reported	1234	(28.0)			12.4%
History of contact to cytomegaly virus	Anti-CMV−	1723	(39.1)			12.0%	0.022
	Anti-CMV+	2688	(60.9)			14.8%
Laboratory data
Creatinine at admission	μmol/L	4400		76.9	61.9–97.2	1.001 [1.000–1.003]	0.104
Creatinine at ET report	μmol/L	4399		79.6	61.9–110	1.000 [0.999–1.002]	0.389