Ischemia/Reperfusion Injury, Its Mechanisms, and Prevention

Publishing date

15 Mar 2012

Status

Published

Submission deadline

15 Sep 2011

Lead Editor

Maciej Kosieradzki¹

Guest Editors

Johann Pratschke² | Jerzy Kupiec-Węgliński³ | Wojciech Rowiński⁴

¹Department of General and Transplantation Surgery, Child Jesus Hospital and Clinics, Medical University of Warsaw, 59 Nowogrodzka Street, 02-005 Warsaw, Poland

²Department für Operative Medizin, Universitätsklinik für Visceral-, Transplantations- und Thoraxchirurgie, Universität Innsbruck, 35 Anichstrasse, 6020 Innsbruck, Austria

³Pathology and Laboratory Medicine, Dumont-UCLA Transplantation Research Center; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

⁴University of Varmia and Masuria School of Medicine, 37 Wojska Polskiego Avenue, 10-228 Olsztyn, Poland

Ischemia/Reperfusion Injury, Its Mechanisms, and Prevention

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Ischemia/reperfusion injury for decades has remained a very important clinical issue and a hot topic for research in organ transplantation. While for years it was called non-immunological injury, we already know that it adds importantly to immunity of a transplanted organ, its antigen presentation, and hence rejection and chronic injury. Ischemia/reperfusion remains a leading cause of early renal graft dysfunction and causes myocardial stunning in heart transplantation and biliary complications after liver transplantation. Due to increasing number of patients on the waiting list and the shortage of organs in recent years, expanded categories of donors have been used. This urge is expected to increase the risk of complications and affect patient safety and cost-effectiveness of transplantation.

Although tremendous progress was made in understanding the mechanism of ischemia/reperfusion injury, effective prevention of this phenomenon in the clinical setting is still difficult.

As this is definitely not a closed chapter, we encourage authors to submit both review and original articles from human and animal studies that will help understand mechanisms of ischemia/ reperfusion injury, its consequences to the auto-/allo-/xenograft models, and develop methods which would allow for some protection of the organ. Potential topics include, but are not limited to:

Mechanisms of tissue injury resulting from ischemia and reperfusion
Genetics and “omics” of a transplant ischemia/reperfusion
Ischemia-reperfusion injury in organs from donors after circulatory definition of death
Viability testing of NHBD-grafts
Impact of donor pretreatment on ischemia/reperfusion of a transplanted organ
Interrelations of ischemia/reperfusion and immunological graft injury
Progress in organ preservation technology

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jtran/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: