Comparison of Oral Tolerance to ApoB and HSP60 Peptides in Preventing Atherosclerosis Lesion Formation in Apob48⁻/Ldlr⁻ Mice

Figure 5

Oral tolerance reduces inflammatory cells in the lesion. (a) Upper panels: representative photomicrographs showing immunofluorescence staining of aortic sinus sections with CD68 (red) in control, ApoB-, Hsp60-treated mice. Scale bar represents 50 μm (𝑁=6), lower panel: percentage of CD68-positive areas from control and treated groups. (b) Upper panels: representative photomicrographs showing immunofluorescence staining of aortic sinus sections with CD4 (red) in control, ApoB-, Hsp60-treated mice. Scale bar represents 50 μm (𝑁=6), lower panel: percentage of CD4-positive areas from control and treated groups. ^∗𝑃≤0.05, ^∗∗𝑃≤0.01, ^∗∗∗𝑃≤0.001.

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