Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes

Table 2

Comparison of VARV, VACV, CPXV, MPXV, and ECTV proteins.

VARV protein	Length (aa)/number of epitopes	Homology, %/number of coincident B-cell epitopes^*
		VARV^**	VACV^**	CPXV^**	MPXV^**	ECTV^**
A30L	110/5	99.1–100.0/5	96.4–97.3/4	97.3–98.2/4	92.7–93.6/3-4	95.6/3
A36R	184/6	100.0/6	93.6–94.1/3	92.0–95.2/3-4	89.8/3	85.3/1
B7R	317/7	99.7–100.0/6-7	92.7–93.1/3-4	92.4–94.0/4-5	92.7/4	91.1/3
F8L	304/8	100.0/8	95.7–96.1/6-7	93.4–95.1/6-7	92.8/6	93.8/6
M1R	250/8	99.6–100.0/7-8	99.2–99.6/7	99.2/7-8	99.2/8	98.4/7

^*% of homology and number of coincident epitopes were computed with respect to VARV strain India-1967 proteins.
^**Data on several strains.