Bacteriophages and Their Derivatives as Biotherapeutic Agents in Disease Prevention and Treatment
Figure 7
Schematic representation of the modular structure (a) and mode of action (b) of phage-encoded endolysins. Most endolysins are characterised by one or two catalytic domains and one cell wall-binding domain involved in substrate recognition. Access of the endolysin to the peptidoglycan (PG) layer is often aided by insertion of the holin into the cytoplasmic membrane (CM).
