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Leukemia Research and Treatment
Volume 2011 (2011), Article ID 373519, 7 pages
doi:10.4061/2011/373519
Research Article

Cytotoxicity of Algae Extracts on Normal and Malignant Cells

Jeremy Bechelli,1 Myra Coppage,2 Karen Rosell,1 and Jane Liesveld1

1Department of Medicine and the James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
2Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA

Received 13 August 2010; Revised 14 October 2010; Accepted 25 October 2010

Academic Editor: Hans G. Drexler

Copyright © 2011 Jeremy Bechelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Molinski, “Marine natural products,” Clinical Advances in Hematology and Oncology, vol. 7, no. 6, pp. 383–385, 2009. View at Scopus
  2. D. Tant, “Urinary tract infection in children,” The British Journal of General Practice, vol. 45, no. 398, p. 506, 1995. View at Scopus
  3. A. Lorenc, Y. Ilan-Clarke, N. Robinson, and M. Blair, “How parents choose to use CAM: a systematic review of theoretical models,” BMC Complementary and Alternative Medicine, vol. 9, article 9, 2009. View at Publisher · View at Google Scholar · View at PubMed
  4. A. Steinsbekk, M. B. Rise, and M. Aickin, “Cross-cultural comparison of visitors to CAM practitioners in the United States and Norway,” Journal of Alternative and Complementary Medicine, vol. 15, no. 11, pp. 1201–1207, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. A. N. Hart, L. A. Zaske, K. M. Patterson, C. Drapeau, and G. S. Jensen, “Natural killer cell activation and modulation of chemokine receptor profile in vitro by an extract from the cyanophyta Aphanizomenon flos-aquae,” Journal of Medicinal Food, vol. 10, no. 3, pp. 435–441, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. J. Subhashini, S. V. K. Mahipal, M. C. Reddy, M. M. Reddy, A. Rachamallu, and P. Reddanna, “Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562,” Biochemical Pharmacology, vol. 68, no. 3, pp. 453–462, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. B. Li, X. Chu, M. Gao, and W. Li, “Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin,” Acta Biochimica et Biophysica Sinica, vol. 42, no. 1, pp. 80–89, 2010. View at Publisher · View at Google Scholar
  8. O. M. Basha, R. A. Hafez, Y. M. El-Ayouty, K. F. Mahrous, M. H. Bareedy, and A. M. Salama, “C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells,” The Egyptian Journal of Immunology, vol. 15, no. 2, pp. 161–167, 2008.
  9. B. V. Pardhasaradhi, A. M. Ali, A. L. Kumari, P. Reddanna, and A. Khar, “Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS,” Molecular Cancer Therapeutics, vol. 2, no. 11, pp. 1165–1170, 2003. View at Scopus
  10. ME Gershwin and A. Belay, Spirulina in Human Nutrition and Health, CRC Press, Boca Raton, Fla, USA, 2008.
  11. A. Kulshreshtha, A. Zacharia J., U. Jarouliya, P. Bhadauriya, G. B. K. S. Prasad, and P. S. Bisen, “Spirulina in health care management,” Current Pharmaceutical Biotechnology, vol. 9, no. 5, pp. 400–405, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Akao, T. Ebihara, H. Masuda et al., “Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice,” Cancer Science, vol. 100, no. 8, pp. 1494–1501, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. N. Pugh and D. S. Pasco, “Characterization of human monocyte activation by a water soluble preparation of Aphanizomenon flos-aquae,” Phytomedicine, vol. 8, no. 6, pp. 445–453, 2001. View at Scopus
  14. K. Preußel, A. Stüken, C. Wiedner, I. Chorus, and J. Fastner, “First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes,” Toxicon, vol. 47, no. 2, pp. 156–162, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. Y. Liu, W. Chen, D. Li, Y. Shen, Y. Liu, and L. Song, “Analysis of paralytic shellfish toxins in Aphanizomenon DC-1 from Lake Dianchi, China,” Environmental Toxicology, vol. 21, no. 3, pp. 289–295, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. Y. Liu, W. Chen, D. Li, Y. Shen, G. Li, and Y. Liu, “First report of aphantoxins in China-waterblooms of toxigenic Aphanizomenon flos-aquae in Lake Dianchi,” Ecotoxicology and Environmental Safety, vol. 65, no. 1, pp. 84–92, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. Y. Kuroiwa, A. Nishikawa, T. Imazawa et al., “A subchronic toxicity study of dunaliella carotene in F344 rats,” Food and Chemical Toxicology, vol. 44, no. 1, pp. 138–145, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. K. N. C. Murthy, A. Vanitha, J. Rajesha, M. M. Swamy, P. R. Sowmya, and G. A. Ravishankar, “In vivo antioxidant activity of carotenoids from Dunaliella salina—a green microalga,” Life Sciences, vol. 76, no. 12, pp. 1381–1390, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. P. Palozza, C. Torelli, A. Boninsegna et al., “Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells,” Cancer Letters, vol. 283, no. 1, pp. 108–117, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. C. Ishikawa, S. Tafuku, T. Kadekaru et al., “Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol,” International Journal of Cancer, vol. 123, no. 11, pp. 2702–2712, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. X. Liu and T. Osawa, “Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food,” Forum of Nutrition, vol. 61, pp. 129–135, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. A. M. Wolf, S. Asoh, H. Hiranuma et al., “Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress,” Journal of Nutritional Biochemistry, vol. 21, no. 5, pp. 381–389, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. I. Nishigaki, P. Rajendran, R. Venugopal, G. Ekambaram, D. Sakthisekaran, and Y. Nishigaki, “Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells,” Phytotherapy Research, vol. 24, no. 1, pp. 54–59, 2010. View at Publisher · View at Google Scholar · View at PubMed
  24. H. Shen, C.-C. Kuo, J. Chou et al., “Astaxanthin reduces ischemic brain injury in adult rats,” The FASEB Journal, vol. 23, no. 6, pp. 1958–1968, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. M. Nakano, N. Orimo, N. Katagiri, M. Tsubata, J. Takahashi, and N. Van Chuyen, “Inhibitory effect of astaxanthin combined with flavangenol on oxidative stress biomarkers in streptozotocin-induced diabetic rats,” International Journal for Vitamin and Nutrition Research, vol. 78, no. 4-5, pp. 175–182, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. R. G. Fassett, H. Healy, R. Driver et al., “Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial,” BMC Nephrology, vol. 9, no. 1, article 17, 2008. View at Publisher · View at Google Scholar · View at PubMed
  27. Y. Nakajima, Y. Inokuchi, M. Shimazawa, K. Otsubo, T. Ishibashi, and H. Hara, “Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo,” Journal of Pharmacy and Pharmacology, vol. 60, no. 10, pp. 1365–1374, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. H.-L. Huang, S.-L. Wu, H.-F. Liao et al., “Induction of apoptosis by three marine algae through generation of reactive oxygen species in human leukemic cell lines,” Journal of Agricultural and Food Chemistry, vol. 53, no. 5, pp. 1776–1781, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. R. Karawita, M. Senevirathne, Y. Athukorala et al., “Protective effect of enzymatic extracts from microalgae against DNA damage induced by H2O2,” Marine Biotechnology, vol. 9, no. 4, pp. 479–490, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. A. M. Gamal-Eldeen, E. F. Ahmed, and M. A. Abo-Zeid, “In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium,” Food and Chemical Toxicology, vol. 47, no. 6, pp. 1378–1384, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. S. Takamatsu, D. G. Nagle, and W. H. Gerwick, “Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion,” Planta Medica, vol. 70, no. 2, pp. 127–131, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus