- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Leukemia Research and Treatment
Volume 2011 (2011), Article ID 373519, 7 pages
Cytotoxicity of Algae Extracts on Normal and Malignant Cells
1Department of Medicine and the James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
2Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Received 13 August 2010; Revised 14 October 2010; Accepted 25 October 2010
Academic Editor: Hans G. Drexler
Copyright © 2011 Jeremy Bechelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- T. Molinski, “Marine natural products,” Clinical Advances in Hematology and Oncology, vol. 7, no. 6, pp. 383–385, 2009.
- D. Tant, “Urinary tract infection in children,” The British Journal of General Practice, vol. 45, no. 398, p. 506, 1995.
- A. Lorenc, Y. Ilan-Clarke, N. Robinson, and M. Blair, “How parents choose to use CAM: a systematic review of theoretical models,” BMC Complementary and Alternative Medicine, vol. 9, article 9, 2009.
- A. Steinsbekk, M. B. Rise, and M. Aickin, “Cross-cultural comparison of visitors to CAM practitioners in the United States and Norway,” Journal of Alternative and Complementary Medicine, vol. 15, no. 11, pp. 1201–1207, 2009.
- A. N. Hart, L. A. Zaske, K. M. Patterson, C. Drapeau, and G. S. Jensen, “Natural killer cell activation and modulation of chemokine receptor profile in vitro by an extract from the cyanophyta Aphanizomenon flos-aquae,” Journal of Medicinal Food, vol. 10, no. 3, pp. 435–441, 2007.
- J. Subhashini, S. V. K. Mahipal, M. C. Reddy, M. M. Reddy, A. Rachamallu, and P. Reddanna, “Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562,” Biochemical Pharmacology, vol. 68, no. 3, pp. 453–462, 2004.
- B. Li, X. Chu, M. Gao, and W. Li, “Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin,” Acta Biochimica et Biophysica Sinica, vol. 42, no. 1, pp. 80–89, 2010.
- O. M. Basha, R. A. Hafez, Y. M. El-Ayouty, K. F. Mahrous, M. H. Bareedy, and A. M. Salama, “C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells,” The Egyptian Journal of Immunology, vol. 15, no. 2, pp. 161–167, 2008.
- B. V. Pardhasaradhi, A. M. Ali, A. L. Kumari, P. Reddanna, and A. Khar, “Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS,” Molecular Cancer Therapeutics, vol. 2, no. 11, pp. 1165–1170, 2003.
- ME Gershwin and A. Belay, Spirulina in Human Nutrition and Health, CRC Press, Boca Raton, Fla, USA, 2008.
- A. Kulshreshtha, A. Zacharia J., U. Jarouliya, P. Bhadauriya, G. B. K. S. Prasad, and P. S. Bisen, “Spirulina in health care management,” Current Pharmaceutical Biotechnology, vol. 9, no. 5, pp. 400–405, 2008.
- Y. Akao, T. Ebihara, H. Masuda et al., “Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice,” Cancer Science, vol. 100, no. 8, pp. 1494–1501, 2009.
- N. Pugh and D. S. Pasco, “Characterization of human monocyte activation by a water soluble preparation of Aphanizomenon flos-aquae,” Phytomedicine, vol. 8, no. 6, pp. 445–453, 2001.
- K. Preußel, A. Stüken, C. Wiedner, I. Chorus, and J. Fastner, “First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes,” Toxicon, vol. 47, no. 2, pp. 156–162, 2006.
- Y. Liu, W. Chen, D. Li, Y. Shen, Y. Liu, and L. Song, “Analysis of paralytic shellfish toxins in Aphanizomenon DC-1 from Lake Dianchi, China,” Environmental Toxicology, vol. 21, no. 3, pp. 289–295, 2006.
- Y. Liu, W. Chen, D. Li, Y. Shen, G. Li, and Y. Liu, “First report of aphantoxins in China-waterblooms of toxigenic Aphanizomenon flos-aquae in Lake Dianchi,” Ecotoxicology and Environmental Safety, vol. 65, no. 1, pp. 84–92, 2006.
- Y. Kuroiwa, A. Nishikawa, T. Imazawa et al., “A subchronic toxicity study of dunaliella carotene in F344 rats,” Food and Chemical Toxicology, vol. 44, no. 1, pp. 138–145, 2006.
- K. N. C. Murthy, A. Vanitha, J. Rajesha, M. M. Swamy, P. R. Sowmya, and G. A. Ravishankar, “In vivo antioxidant activity of carotenoids from Dunaliella salina—a green microalga,” Life Sciences, vol. 76, no. 12, pp. 1381–1390, 2005.
- P. Palozza, C. Torelli, A. Boninsegna et al., “Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells,” Cancer Letters, vol. 283, no. 1, pp. 108–117, 2009.
- C. Ishikawa, S. Tafuku, T. Kadekaru et al., “Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol,” International Journal of Cancer, vol. 123, no. 11, pp. 2702–2712, 2008.
- X. Liu and T. Osawa, “Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food,” Forum of Nutrition, vol. 61, pp. 129–135, 2009.
- A. M. Wolf, S. Asoh, H. Hiranuma et al., “Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress,” Journal of Nutritional Biochemistry, vol. 21, no. 5, pp. 381–389, 2009.
- I. Nishigaki, P. Rajendran, R. Venugopal, G. Ekambaram, D. Sakthisekaran, and Y. Nishigaki, “Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells,” Phytotherapy Research, vol. 24, no. 1, pp. 54–59, 2010.
- H. Shen, C.-C. Kuo, J. Chou et al., “Astaxanthin reduces ischemic brain injury in adult rats,” The FASEB Journal, vol. 23, no. 6, pp. 1958–1968, 2009.
- M. Nakano, N. Orimo, N. Katagiri, M. Tsubata, J. Takahashi, and N. Van Chuyen, “Inhibitory effect of astaxanthin combined with flavangenol on oxidative stress biomarkers in streptozotocin-induced diabetic rats,” International Journal for Vitamin and Nutrition Research, vol. 78, no. 4-5, pp. 175–182, 2008.
- R. G. Fassett, H. Healy, R. Driver et al., “Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial,” BMC Nephrology, vol. 9, no. 1, article 17, 2008.
- Y. Nakajima, Y. Inokuchi, M. Shimazawa, K. Otsubo, T. Ishibashi, and H. Hara, “Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo,” Journal of Pharmacy and Pharmacology, vol. 60, no. 10, pp. 1365–1374, 2008.
- H.-L. Huang, S.-L. Wu, H.-F. Liao et al., “Induction of apoptosis by three marine algae through generation of reactive oxygen species in human leukemic cell lines,” Journal of Agricultural and Food Chemistry, vol. 53, no. 5, pp. 1776–1781, 2005.
- R. Karawita, M. Senevirathne, Y. Athukorala et al., “Protective effect of enzymatic extracts from microalgae against DNA damage induced by H2O2,” Marine Biotechnology, vol. 9, no. 4, pp. 479–490, 2007.
- A. M. Gamal-Eldeen, E. F. Ahmed, and M. A. Abo-Zeid, “In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium,” Food and Chemical Toxicology, vol. 47, no. 6, pp. 1378–1384, 2009.
- S. Takamatsu, D. G. Nagle, and W. H. Gerwick, “Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion,” Planta Medica, vol. 70, no. 2, pp. 127–131, 2004.