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Leukemia Research and Treatment
Volume 2011 (2011), Article ID 428960, 4 pages
http://dx.doi.org/10.4061/2011/428960
Review Article

Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia

Department of Internal Medicine III, Center for Integrated Oncology (CIO), University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany

Received 30 August 2011; Accepted 21 October 2011

Academic Editor: Spiro Konstantinov

Copyright © 2011 Y. Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.