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Leukemia Research and Treatment
Volume 2012 (2012), Article ID 250432, 4 pages
http://dx.doi.org/10.1155/2012/250432
Research Article

Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients

1LOSEV the Foundation for Children with Leukemia, Ankara, Turkey
2Department of Pediatric Genetics, Ankara University, Ankara, Turkey
3Department of Pediatric Haematology, G├╝lhane Military Medical Academy, Ankara, Turkey
4TOBB-ETU Hospital, Ankara, Turkey

Received 6 September 2011; Accepted 5 December 2011

Academic Editor: Helena Kempski

Copyright © 2012 Dilara Fatma Akın et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5,1%) of the patients carried the PT 20210 G-A heterozygous mutation. Of the 135 patients, only three had thrombotic event, none of which had these two mutations, which is common in Turkish population. Our findings revealed a controversial compared to the previous reports, which needs further investigation.