PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells

Figure 8

PKCδ plays a critical role in ATRA-induced terminal differentiation of APL cells. Inhibition of PKCδ blocked ATRA-induced granulocytic differentiation of NB4 cells. NB4 cells were pretreated with rottlerin (4 μM) for 4 h before adding ATRA (1 μM). After 48 h of ATRA treatment, cells were collected and analyzed for CD11b positivity as a measure of granulocytic differentiation.