A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia

Table 1

(a) Probes used for characterization of the three-way translocation, their location, and obtained results. (b) Probes used for characterization of the in aCGH detected deletions, their location, and obtained results.

(a)

Cytoband	Location hg19	Probe	Result for derivative chromosomes
2p24.3	chr2:	RP11-119F22	Signal on der(9); no split signal
	16,014,784–16,140,647
2p23.3	chr2:	RP11-106G13	Signal on der(9); no split signal
	26,967,697–27,136,688
2p23.2	chr2:	SPEC ALK	Signal on der(9); no split signal
	29,415,640–29,447,593
9p22.1	chr9:	RP11-503K16	Signal on der(18); no split signal
	18,717,972–18,718,524
9p22.1	chr9:	RP11-513M16	Signal on der(18); no split signal
	19,371,384–19,371,943
9p21.3	chr9:	RP11-15P13	Signal on der(18); no split signal
	20,182,493–20,361,132
9p21.3	chr9:	MLLT3	MLLT3-gene signal on der(18); no split signal
	20,344,968–20,621,872
9p21.3	chr9:	SPEC p16	Deletion on der(9) and/or der(18)
	21,967,751–21,975,132
9p21.3	chr9:	RP11-946B6	Deletion on der(9) and/or der(18); ish 9p21.3(RP11-946B6x0)[]
	23,608,612–23,790,449
9p21.2	chr9:	RP11-438B23	Signal on der(9); no split signal
	27,937,615–27,944,495
18q21.32	chr18:	MALT1	MALT1-gene signal on der(18); no split signal
	56,338,618–56,417,370
18q21	chr18:	BCL2	BCL2-gene signal on der(2); no split signal
	60,985,282–60,985,899

(b)

Cytoband	Location [hg19]	Probe	Result for derivative chromosomes
9p21.3	chr9: 21,967,751–21,975,132	SPEC p16	ish   9p21.3(p16x1)[]; nuc ish 9p21(p16x0)[]/9p21(p16x1)[]/; 9p21(p16x2)[]
13q14.2	chr13: 48,920,000–49,140,000	LSI 13 = 1	nuc ish 13q14.2(1x0)[]/; 13q14.2(1x1)[]/; 13q14.2(1x2)[121]