Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective
Figure 13
Clonality assessment in B cell lymphoma. In a normal or reactive condition, B cells are composed of heterogeneous populations of B cells expression polyclonal immunoglobulin (heavy and light chain) (a). PCR assay will show different size (smear on the gel) (b) or Gaussian distribution of peaks (c). In a clonal expansion process, there is predominance of one population of B cells with monotypic immunoglobulin (d). PCR assay demonstrates a single band on gel (e) or a predominant peak (f).
