Clinical Features and Prognosis of CD20 Negative Aggressive B-Cell Non-Hodgkins Lymphoma
Figure 1
Hematoxylin-Eosin (H&E) and immunohistochemical features of Patient 1. (a) H&E shows medium to large-sized lymphoma cells with eccentric nuclei, heterochromatin at the edges of the nuclear membrane, and basophilic cytoplasm. These changes impart a plasmacytoid appearance. (b) Lymphoma does not stain for CD 20. (c) CD 138 stain demonstrates variable positive staining in significant number of neoplastic cells. (d) Ki-67 staining shows high proliferative index.
