Impact of BMI and Gender on Outcomes in DLBCL Patients Treated with R-CHOP: A Pooled Study from the LYSA

Table 4

Impact of gender stratification on BMI.

Gender; (male versus female)	BMI < 18.5	BMI 18.5–25	BMI > 25
PFS	𝑃=0.9682; HR = 1.024; 95% CI (0.32–3.27)	𝑃=0.0455; HR = 1.324; 95% CI (1.00–1.74)	𝑃=0.312; HR = 1.147; 95% CI (0.88–1.49)
OS	𝑃=0.3246; HR = 1.88; 95% CI (0.52–6.82)	𝑃=0.0276; HR = 1.427; 95% CI (1.038–1.96)	𝑃=0.9899; HR = 1.00; 95% CI (0.747–1.344)

The impact of gender varied with BMI. Gender had no impact on PFS in the subgroup of patients with a low BMI (<18.5); however, men with a low BMI tended to have a shorter OS than women with a BMI < 18.5. Male gender was a relevant bad prognostic factor for OS and PFS in the subgroup of patients with BMI scores between 18.5 and 25. Finally, gender was not a relevant prognostic factor in patients with a BMI > 25.