Metal-Based Drugs
Volume 3 (1996), Issue 5, Pages 211-217
doi:10.1155/MBD.1996.211
Pharmacological Role of Anions (Sulphate, Nitrate, Oxalate and
Acetate) on the Antibacterial Activity of Cobalt(II), Copper(II)
and Nickel(II) Complexes With Nicotinoylhydrazine-Derived ONO,
NNO and SNO Ligands
Department of Chemistry, Islamia University, Bahawalpur, and Bahauddin Zakariya University, Multan, Pakistan
Received 10 September 1996; Accepted 17 September 1996
Abstract
Mixed ligands biologically active complexes of cobalt(II), copper(II) and nickel(II) with
nicotinoylhydrazine-derived ONO, NNO and SNO donor schiff-base ligands having the
same metal ion but different anions such as sulphate, nitrate, oxalate and acetate have been
synthesised and characterised on the basis of their physical, analytical and spectral data. In
order to evaluate the role of anions on their bioability, these ligands and their synthesised
metal complexes with various anions have been screened against bacterial species such as
Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and the title studies have proved a definative role of anions in increasing the biological activity