Metal-Based Drugs 
Volume 4 (1997), Issue 5, Pages 267-272
doi:10.1155/MBD.1997.267

Structural and Biological Behaviour of Co(II), Cu(II) and Ni(II) Metal Complexes of Some Amino Acid Derived Schiff-Bases

Zahid H. Chohan,1 M. Praveen,1 and A. Ghaffar2

1Department of Chemistry, University of Aberdeen, Scotland, Old Aberdeen AB9 2UE, UK
2Department of Chemistry, Islamia University, Bahawalpur, Pakistan

Received 26 March 1997; Accepted 25 April 1997

Abstract

Biologically active tridentate amino acid (Alanine, Glycine & Tyrosine) derived Schiff-bases and their Co(II), Cu(II) & Ni(II) complexes have been synthesised and characterised on the basis of their conductance and magnetic measurements, elemental analysis and C13-NMR, H1-NMR, IR and electronic spectral data. These Schiff-bases and their complexes have been evaluated for their antibacterial activity against bacterial species such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumonae, Proteus vulgarus and Pseudomonas aeruginosa and this activity data show the metal complexes to be more antibacterial than the Schiff-bases against one or more bacterial species.