Metal-Based Drugs
Volume 5 (1998), Issue 6, Pages 347-354
doi:10.1155/MBD.1998.347
Synthesis, Ligational and Biological Properties of Cobalt(II),
Copper(II), Nickel(II) and Zinc(II) Complexes With
Pyrazinedicarboxaimide Derived Furanyl, Thienyl and Pyrrolyl Compounds
1Department of Chemistry, Islamia University, Bahavalpur, Pakistan
2Department of Chemistry, Washington University, St. Louis 63130, USA
3Himont Pharmaceutical and Chemical Laboratories, Lahore, Pakistan
Received 21 October 1998; Accepted 11 November 1998
Abstract
Preparation, ligational and biological properties of some pyrazinedicarboxaimide derived
furanyl, thienyl and pyrrolyl compounds with Co(ll), Cu(ll), Ni(ll) and Zn(ll) metals are
described. Magnetic moments, electronic, infrared, nuclear magnetic resonance spectra and
elemental analysis data indicate that co-ordination of the ligands with the metal ions take
place through the pyrazine ring nitrogen, azomethine nitrogen and heteroatom of
heterocyclic ring system. The compounds are all novel and are proposed to possess an
octahedral geometry for Co(ll) and Ni(ll), and a distorted octahedral geometry for Cu(ll) and
Zn(ll) complexes. The comparative biological properties of the title ligands and their metal
chelates against different bacterial species are also described.