Metal-Based Drugs 
Volume 5 (1998), Issue 5, Pages 267-274
doi:10.1155/MBD.1998.267

Studies on Some Biologically Cobalt(II), Copper(II) and Zinc(II) Complexes With ONO, NNO and SNO Donor Pyrazinoylhydrazine-Derived Ligands

Zahid H. Chohan,1 Marapaka Praveen,2 and Syed K. A. Sherazi1

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Department of Chemistry, Washington University, St. Louis 63130, MO, USA

Received 28 May 1998; Accepted 26 June 1998

Abstract

Biologically active complexes of Co(II), Ni(II), Cu(II) and Zn(II) with novel ONO, NNO and SNO donor pyrazinoylhydrazine-derived compounds have been prepared and characterized on the basis of analytical data and various physicochemical studies. Distorted octahedral structures for all the complexes have been proposed. The synthesized ligands and their complexes have been screened for their antibacterial activity against bacterial species Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumonae. The activity data show the metal complexes to be more active than the parent free ligands against one or more bacterial species.