Metal-Based Drugs 
Volume 6 (1999), Issue 3, Pages 149-152
doi:10.1155/MBD.1999.149

Ferrocene-Derived Pyrazinoyl and Nicotinoyl Schiff-Bases: Their Synthesis, Characterization and Biological Properties

Zahid H. Chohan1 and M. Praveen2

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Department of Chemistry, Washington University, St. Louis 63130, Washington, USA

Received 29 March 1999; Accepted 21 April 1999

Abstract

A novel class of acetylferrocene-derived Schiff-bases such as 2-pyrazinoyl-1-(2-ferroceneylmethylene)- hydrazide (HL1) and 2-nicotinoyl-1-(2-ferrocenylmethylene)hydrazide (HL2) have been synthesized and characterized by their IR, H1 NMR, C13 NMR and microanalytical date. The biological effect induced due to the coupling of ferrocene molecule with the aroylhydrazines e.g., pyrazinoylhydrazine and nicotinoylhydrazine has been studied against bacterial species such as Escherichia coli, Pseudomonas aeruginosa , Staphylococcus aureus and Klebsiella pneumonae.