Metal-Based Drugs 
Volume 8 (2001), Issue 3, Pages 171-177
doi:10.1155/MBD.2001.171

Copper (II) Acylhydrazinates. Their Synthesis and Characterization

Zahid H. Chohan,1 M. A. Farooq,1 and Claudiu T. Supuran2

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Laboratorio di Chimica Inorgania e Bioinorganica, Uriversita degli Studi, Via Gino Capponi 7, Firenze 1-50121, Italy

Received 22 July 2000; Accepted 31 August 2000

Abstract

Acylhydrazine derived furanyl and thienyl Schiff bases and their Cu(II) complexes have been prepared and characterized on the basis of their physical, spectral and analytical data. The preferred enolic form of the Schiff base function as a tetradentate ligand during coordination to the metal ion yielding a square planar complex. The Schiff bases and their complexes with different anions were tested for their antibacterial activity against bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa andKlebsiella pneumonae.