Metal-Based Drugs 
Volume 8 (2002), Issue 5, Pages 263-267
doi:10.1155/MBD.2002.263

Antibacterial Role of SO42− , NO3− , C2O42− and CH3CO2− Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff Base

Zahid H. Chohan,1 Humayun Pervez,2 Abdul Rauf,1 and Claudiu T. Supuran3

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan
3University of Florence, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Rm 188, Polo Scientifico , Firenze 50019-Sesto Fiorentino, Italy

Received 8 February 2002; Accepted 19 February 2002

Abstract

A condensation reaction of 2-amino-1,3,4-thiadiazole with 2-pyrrolecarboxaldehyde to form tridentate NNN donor Schiff base has been performed. The prepared Schiff base was further used for the formation of metal complexes having stoichiometry [M(L)2]Xn , where M=Cu(II) or Zn(II), L=N-(2-pyrrolylmethylene)-2-amino-1,3,4-thiadiazole, X=SO42− , NO3− , C2O42− or CH3CO2− and n=1 or 2. The new compounds described here have been characterized by their physical, spectral and analytical data, and have been screened against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of the Schiff base increased upon chelation/complexation, having the same metal ion (cation) but different anions opening up a novel approach in finding new ways to fight against antibiotic resistant strains.