Metal-Based Drugs 
Volume 8 (2002), Issue 5, Pages 287-291
doi:10.1155/MBD.2002.287

Antibacterial Co(II) and Ni(II) Complexes of N-(2-Furanylmethylene)-2-Aminothiadiazole and Role of SO42− ,NO3− , C2O42− and CH3CO2− anions on Biological Properties

Zahid H. Chohan,1 Abdul Rauf,1 and Claudiu T. Supuran2

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2University of Florence, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Rm 188, Polo Scientifico, Firenze 50019-Sesto Fiorentino, Italy

Received 7 March 2002; Accepted 28 March 2002

Abstract

Co(II) and Ni(II) complexes with a Schiff base, N-(2-furanylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The synthesized Schiff-bases act as tridentate ligands during the complexation reaction with Co(II) and Ni(II. metal ions. They possess the composition [M(L)2]Xn (where M=Co(II) or Ni(II), L=, X=NO3− , SO42− , C2O42− or CH3CO2− and n=1 or 2) and show an octahedral geometry. In order to evaluate the effect of anions upon chelation, the Schiff-base and its complexes have been screened for antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.