Review Article
Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery
Table 1
T. brucei (Tb), T. cruzi (Tc), and L. mexicana (Lm) G6PDH kinetic constants for an ordered bi-bi-reaction mechanism.
| Source | K
G6P | K
NADP+ | V1 | k
cat | K
iG6P | (μM) | (μM) | (nmoles of NADPHs−1) | (s−1) | (μM) |
| Tb | 57.8 ± 2.4 | 9.4 ± 0.4 | 36.2 ± 1.5 | 16.4 ± 0.6 | 47.6 ± 1.9 | Tc | 206.0 ± 4.2 | 22.5 ± 1.2 | 77.7 ± 2.5 | 57.1 ± 1.9 | 105.3 ± 4.6 | Lm | 74.5 ± 3.0 | 12.1 ± 0.5 | 31.2 ± 1.2 | 22.2 ± 0.9 | 86.4 ± 3.5 |
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Data from Cordeiro et al. [45, 46].
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