Research Article

Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity

Figure 1

Typical differential fluorimetry scans of TbINO1. Differential fluorimetric scans were performed and analysed as described in Experimental. TbINO1 + DMSO (control) dotted line, TbINO1 + 4 mM 2-deoxy-glucose-6-phosphate (positive control) solid line, and TbINO1 + 1 mM compound 520, dashed line.
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