Research Article
Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity
Table 3
Structure activity relationship for trypanocidal activity of analogues of the diamine compound 269.
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aArbitrary Library number. bCAS numbers are unique identifiers assigned by the “Chemical Abstracts Service” to describe every chemical described in the open access scientific literature. cFor trypanocidal and cytotoxicity activity, see Section 2 for details and values are ED50s ± SD (). dSelectivity index: T. brucei ED50/HeLa ED50. |