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Molecular Biology International
Volume 2011 (2011), Article ID 437301, 7 pages
http://dx.doi.org/10.4061/2011/437301
Review Article

MiR-146a in Immunity and Disease

Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland

Received 17 December 2010; Accepted 17 February 2011

Academic Editor: Alessandro Desideri

Copyright © 2011 Nicole Rusca and Silvia Monticelli. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of the innate as well as adaptive immunity. Given its importance in regulating key cellular functions, it is not surprising that miR-146a expression was also found dysregulated in different types of tumors. In this paper, we summarize recent progress in understanding the role of miR-146a in innate and adaptive immune responses, as well as in disease.