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Molecular Biology International
Volume 2011 (2011), Article ID 437301, 7 pages
MiR-146a in Immunity and Disease
Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Received 17 December 2010; Accepted 17 February 2011
Academic Editor: Alessandro Desideri
Copyright © 2011 Nicole Rusca and Silvia Monticelli. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- F. Navarro and J. Lieberman, “Small RNAs guide hematopoietic cell differentiation and function,” Journal of Immunology, vol. 184, no. 11, pp. 5939–5947, 2010.
- A. E. Pasquinelli, S. Hunter, and J. Bracht, “MicroRNAs: a developing story,” Current Opinion in Genetics and Development, vol. 15, no. 2, pp. 200–205, 2005.
- K. Basso, P. Sumazin, P. Morozov et al., “Identification of the human mature B cell miRNome,” Immunity, vol. 30, no. 5, pp. 744–752, 2009.
- P. Landgraf, M. Rusu, R. Sheridan et al., “A mammalian microRNA expression atlas based on small RNA library sequencing,” Cell, vol. 129, no. 7, pp. 1401–1414, 2007.
- S. Monticelli, K. M. Ansel, C. Xiao et al., “MicroRNA profiling of the murine hematopoietic system,” Genome Biology, vol. 6, no. 8, p. R71, 2005.
- J. R. Neilson, G. X. Y. Zheng, C. B. Burge, and P. A. Sharp, “Dynamic regulation of miRNA expression in ordered stages of cellular development,” Genes and Development, vol. 21, no. 5, pp. 578–589, 2007.
- H. Wu, J. R. Neilson, P. Kumar et al., “miRNA profiling of naïve, effector and memory CD8 T cells,” PLoS ONE, vol. 2, no. 10, article e1020, 2007.
- G. A. Calin and C. M. Croce, “MicroRNA signatures in human cancers,” Nature Reviews Cancer, vol. 6, no. 11, pp. 857–866, 2006.
- C. Kanellopoulou and S. Monticelli, “A role for microRNAs in the development of the immune system and in the pathogenesis of cancer,” Seminars in Cancer Biology, vol. 18, no. 2, pp. 79–88, 2008.
- L.-F. Lu, M. P. Boldin, A. Chaudhry et al., “Function of miR-146a in controlling treg cell-mediated regulation of Th1 responses,” Cell, vol. 142, no. 6, pp. 914–929, 2010.
- C. Chassin, M. Kocur, J. Pott et al., “MiR-146a mediates protective innate immune tolerance in the neonate intestine,” Cell Host and Microbe, vol. 8, no. 4, pp. 358–368, 2010.
- K. D. Taganov, M. P. Boldin, K. J. Chang, and D. Baltimore, “NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 33, pp. 12481–12486, 2006.
- G. Curtale, F. Citarella, C. Carissimi et al., “An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes,” Blood, vol. 115, no. 2, pp. 265–273, 2010.
- M. A. Nahid, K. M. Pauley, M. Satoh, and E. K. L. Chan, “miR-146a is critical for endotoxin-induced tolerance: implication in innate immunity,” Journal of Biological Chemistry, vol. 284, no. 50, pp. 34590–34599, 2009.
- J. Jurkin, Y. M. Schichl, R. Koeffel et al., “miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation,” Journal of Immunology, vol. 184, no. 9, pp. 4955–4965, 2010.
- M. M. Perry, S. A. Moschos, A. E. Williams, N. J. Shepherd, H. M. Larner-Svensson, and M. A. Lindsay, “Rapid changes in microrna-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells1,” Journal of Immunology, vol. 180, no. 8, pp. 5689–5698, 2008.
- C. Labbaye, I. Spinello, M. T. Quaranta et al., “A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis,” Nature Cell Biology, vol. 10, no. 7, pp. 788–801, 2008.
- D. Bhaumik, G. K. Scott, S. Schokrpur, C. K. Patil, J. Campisi, and C. C. Benz, “Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells,” Oncogene, vol. 27, no. 42, pp. 5643–5647, 2008.
- X. Wang, S. Tang, S. Y. Le et al., “Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth,” PLoS ONE, vol. 3, no. 7, article e2557, 2008.
- S. L. Lin, A. Chiang, D. Chang, and S. Y. Ying, “Loss of mir-146a function in hormone-refractory prostate cancer,” RNA, vol. 14, no. 3, pp. 417–424, 2008.
- Y. Li, T. G. VandenBoom, Z. Wang et al., “miR-146a suppresses invasion of pancreatic cancer cells,” Cancer Research, vol. 70, no. 4, pp. 1486–1495, 2010.
- K. Jazdzewski, E. L. Murray, K. Franssila, B. Jarzab, D. R. Schoenberg, and A. De La Chapelle, “Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 20, pp. 7269–7274, 2008.
- J. Hou, P. Wang, L. Lin et al., “MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2,” Journal of Immunology, vol. 183, no. 3, pp. 2150–2158, 2009.
- J. E. Cameron, Q. Yin, C. Fewell et al., “Epstein-Barr virus latent membrane protein 1 induces cellular microRNA miR-146a, a modulator of lymphocyte signaling pathways,” Journal of Virology, vol. 82, no. 4, pp. 1946–1958, 2008.
- M. A. Newman and S. M. Hammond, “Emerging paradigms of regulated microRNA processing,” Genes and Development, vol. 24, no. 11, pp. 1086–1092, 2010.
- J. G. Ruby, C. H. Jan, and D. P. Bartel, “Intronic microRNA precursors that bypass Drosha processing,” Nature, vol. 448, no. 7149, pp. 83–86, 2007.
- B. S. Cobb, T. B. Nesterova, E. Thompson et al., “T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer,” Journal of Experimental Medicine, vol. 201, no. 9, pp. 1367–1373, 2005.
- S. B. Koralov, S. A. Muljo, G. R. Galler et al., “Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage,” Cell, vol. 132, no. 5, pp. 860–874, 2008.
- S. A. Muljo, K. M. Ansel, C. Kanellopoulou, D. M. Livingston, A. Rao, and K. Rajewsky, “Aberrant T cell differentiation in the absence of Dicer,” Journal of Experimental Medicine, vol. 202, no. 2, pp. 261–269, 2005.
- D. O'Carroll, I. Mecklenbrauker, P. P. Das et al., “A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway,” Genes and Development, vol. 21, no. 16, pp. 1999–2004, 2007.
- C. Z. Chen, L. Li, H. F. Lodish, and D. P. Bartel, “MicroRNAs modulate hematopoietic lineage differentiation,” Science, vol. 303, no. 5654, pp. 83–86, 2004.
- Q. J. Li, J. Chau, P. J. R. Ebert et al., “miR-181a is an intrinsic modulator of T cell sensitivity and selection,” Cell, vol. 129, no. 1, pp. 147–161, 2007.
- R. M. O'Connell, D. S. Rao, A. A. Chaudhuri et al., “Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder,” Journal of Experimental Medicine, vol. 205, no. 3, pp. 585–594, 2008.
- A. Rodriguez, E. Vigorito, S. Clare et al., “Requirement of bic/microRNA-155 for normal immune function,” Science, vol. 316, no. 5824, pp. 608–611, 2007.
- T. H. Thai, D. P. Calado, S. Casola et al., “Regulation of the germinal center response by MicroRNA-155,” Science, vol. 316, no. 5824, pp. 604–608, 2007.
- A. Ventura, A. G. Young, M. M. Winslow et al., “Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters,” Cell, vol. 132, no. 5, pp. 875–886, 2008.
- E. Vigorito, K. L. Perks, C. Abreu-Goodger et al., “microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells,” Immunity, vol. 27, no. 6, pp. 847–859, 2007.
- C. Xiao, D. P. Calado, G. Galler et al., “MiR-150 controls B cell differentiation by targeting the transcription factor c-myb,” Cell, vol. 131, no. 1, pp. 146–159, 2007.
- B. P. Lewis, C. B. Burge, and D. P. Bartel, “Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets,” Cell, vol. 120, no. 1, pp. 15–20, 2005.
- F. Sallusto and A. Lanzavecchia, “Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity,” European Journal of Immunology, vol. 39, no. 8, pp. 2076–2082, 2009.
- R. Sandberg, J. R. Neilson, A. Sarma, P. A. Sharp, and C. B. Burge, “Proliferating cells express mRNAs with shortened untranslated regions and fewer microRNA target sites,” Science, vol. 320, no. 5883, pp. 1643–1647, 2008.
- K. D. Taganov, M. P. Boldin, and D. Baltimore, “MicroRNAs and Immunity: tiny players in a big field,” Immunity, vol. 26, no. 2, pp. 133–137, 2007.
- F. Bazzoni, M. Rossato, M. Fabbri et al., “Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 13, pp. 5282–5287, 2009.
- G. Liu, A. Friggeri, Y. Yang, Y. J. Park, Y. Tsuruta, and E. Abraham, “miR-147, a microRNA that is induced upon toll-like receptor stimulation, regulates murine macrophage inflammatory responses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 37, pp. 15819–15824, 2009.
- R. M. O'Connell, K. D. Taganov, M. P. Boldin, G. Cheng, and D. Baltimore, “MicroRNA-155 is induced during the macrophage inflammatory response,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 5, pp. 1604–1609, 2007.
- F. J. Sheedy, E. Palsson-Mcdermott, E. J. Hennessy et al., “Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21,” Nature Immunology, vol. 11, no. 2, pp. 141–147, 2010.
- H. He, K. Jazdzewski, W. Li et al., “The role of microRNA genes in papillary thyroid carcinoma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 19075–19080, 2005.
- Y. Suzuki, H. W. Kim, M. Ashraf, and H. Haider, “Diazoxide potentiates mesenchymal stem cell survival via NF-κB-dependent miR-146a expression by targeting Fas,” American Journal of Physiology, vol. 299, no. 4, pp. H1077–H1082, 2010.
- S. E. Godshalk, T. Paranjape, S. Nallur, et al., “A variant in a MicroRNA complementary site in the UTR of the KIT oncogene increases risk of acral melanoma,” Oncogene, vol. 30, no. 13, pp. 1542–1550, 2011.
- W. Yang, T. P. Chendrimada, Q. Wang et al., “Modulation of microRNA processing and expression through RNA editing by ADAR deaminases,” Nature Structural and Molecular Biology, vol. 13, no. 1, pp. 13–21, 2006.
- K. Nishikura, “Functions and regulation of RNA editing by ADAR deaminases,” Annual Review of Biochemistry, vol. 79, pp. 321–349, 2010.
- Y. Kawahara, B. Zinshteyn, P. Sethupathy, H. Iizasa, A. G. Hatzigeorgiou, and K. Nishikura, “Redirection of silencing targets by adenosine-to-inosine editing of miRNAs,” Science, vol. 315, no. 5815, pp. 1137–1140, 2007.
- N. Schöler, C. Langer, H. Döhner, C. Buske, and F. Kuchenbauer, “Serum microRNAs as a novel class of biomarkers: a comprehensive review of the literature,” Experimental Hematology, vol. 38, no. 12, pp. 1126–1130, 2010.
- P. S. Mitchell, R. K. Parkin, E. M. Kroh et al., “Circulating microRNAs as stable blood-based markers for cancer detection,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 30, pp. 10513–10518, 2008.
- X. Chen, Y. Ba, L. Ma et al., “Characterization of microRNAs in serumml: a novel class of biomarkers for diagnosis of cancer and other diseases,” Cell Research, vol. 18, no. 10, pp. 997–1006, 2008.