MiR-146a in Immunity and Disease

Table 1

Summary of the described roles for miR-146a in immune responses and disease, with indicated references and known targets.

Ref.	Expression/Function	Targets
	Mouse
[5]	Differential expression in Th1/Th2 cells
[10]	Impaired Treg function in mice lacking miR-146a	STAT1
[11]	Provided protection from bacteria induced epithelial damage in neonates	IRAK1
	Human
[12]	Attenuated TLR4 signaling in monocytes	IRAK1, TRAF6
[13]	Regulated activation induced cell death and IL-2 expression in Jurkat T cells	FADD
[14]	Contributed to the establishment of endotoxin tolerance in monocytes	IRAK1, TRAF6
[15]	Desensitized Langerhans cells to inappropriate TLR signaling
[16]	Negatively regulated inflammatory response in lung epithelial cells
[17]	Controlled megakaryopoiesis	CXCR4
[18]	Reduced migration and invasion capacity of breast cancer cells	IRAK1, TRAF6
[19]	Promoted cell proliferation in cervical cancer
[20]	Tumor suppressor in hormone-refractory prostate cancer	ROCK1
[21]	Suppressed invasion of pancreatic cancer cells	EGFR, IRAK1
[22]	SNP in pre-miR-146a predisposes to papillary thyroid carcinoma
	Viruses
[23]	Promoted VSV replication in macrophages	IRAK1, IRAK2, TRAF6
[24]	EBV-encoded LMP1 induced cellular miR-146a expression