Table 1: Summary of the described roles for miR-146a in immune responses and disease, with indicated references and known targets.

Ref.Expression/FunctionTargets

Mouse
[5]Differential expression in Th1/Th2 cells
[10]Impaired Treg function in mice lacking miR-146aSTAT1
[11]Provided protection from bacteria induced epithelial damage in neonatesIRAK1

Human
[12]Attenuated TLR4 signaling in monocytesIRAK1, TRAF6
[13]Regulated activation induced cell death and IL-2 expression in Jurkat T cellsFADD
[14]Contributed to the establishment of endotoxin tolerance in monocytesIRAK1, TRAF6
[15]Desensitized Langerhans cells to inappropriate TLR signaling
[16]Negatively regulated inflammatory response in lung epithelial cells
[17]Controlled megakaryopoiesisCXCR4
[18]Reduced migration and invasion capacity of breast cancer cellsIRAK1, TRAF6
[19]Promoted cell proliferation in cervical cancer
[20]Tumor suppressor in hormone-refractory prostate cancerROCK1
[21]Suppressed invasion of pancreatic cancer cellsEGFR, IRAK1
[22]SNP in pre-miR-146a predisposes to papillary thyroid carcinoma

Viruses
[23]Promoted VSV replication in macrophagesIRAK1, IRAK2, TRAF6
[24]EBV-encoded LMP1 induced cellular miR-146a expression