Molecular Biology International

Review Article

Copper and Its Complexes in Medicine: A Biochemical Approach

Table 1

Binary Cu(II) Complexes that exhibit biological activity.
LigandCoordination modeType of complex aBiological activityReference
2,6-bis (benzimidazo-2-yl) pyridine594529.fig.001LCuCl2 or[LCu(H2O)2(NO3)]+Protease mimetic[59]
Pyridyl-2-carboxamidrazone594529.fig.002LCuCl2Anticancer[60]
6-(2-chlorobenzyl amino) purine594529.fig.003[(LH)2CuCl3]+Potent anticancer, inhibiting cell growth of various types of cancer[61]
5-nitrofuran-2-carboxaldehyde thiosemicarbazone or thiophene-2-carboxaldehyde thiosemicarbazone594529.fig.004L2CuCl2Antiamoebic[62]
4-nitroacetophenone thiosemicarbazone594529.fig.005 L2CuAntitrypano somal[63]
2,4-diiodo-6-(pyridine-2-yl methylamino) methyl phenolate594529.fig.006(L-H)CuCl or[L(L-H)Cu]+Proteasome inhibitor, apoptosis inducer[64]
Pyrolidine dithiocarbamate594529.fig.007 L2CuProteasome inhibitor, apoptosis inducer[65]
Ciproflaxin594529.fig.008Enoxacin(R  = C2H5-)594529.fig.009 L2CuAntibacterial[66]
(5-bromo-2-hydroxyphenyl)methylidene amino-N-(pyrimidin-2-yl)benzene sulfonamides594529.fig.0010(L-H)2CuAntibacterial[67]
a(LH) denotes protonated ligand; (L-H) denotes deprotonated ligand.