Structure and Function of the Small MutS-Related Domain
Figure 1
Amino acid sequence alignments of family 1, 2, and 3 Smr domains. (a) Family 1 Smr domains. The schematic representation of T. thermophilus MutS2 is shown at the top of the panel. The location of the secondary structure elements of T. thermophilus MutS2 Smr domain is shown above the sequences. Glu-677 and His-701 in T. thermophilus MutS2 are indicated by numbers above the sequences. Red and blue characters indicate residues whose chemical characteristics are conserved in all and 5 of the 6 species, respectively. The highly conserved HGKG motif is underlined. The 100% conserved acidic residues are indicated with asterisks. (b) Family 2 Smr domains. The schematic representation of H. sapiens N4BP2 is shown at the top of the panel. The location of the secondary structure elements of the Smr domain of H. sapiens N4BP2 is shown above the sequences. Lys-1722, Ser-1735, Arg-1741, Lys-1743, and Arg-1756 are indicated by numbers above the sequences. Red and blue characters indicate residues whose chemical characteristics are conserved in all and 4 of the 5 species, respectively. The 100% conserved acidic residues are indicated with asterisks. (c) Family 3 Smr domains. The schematic representation of E. coli YdaL is shown at the top of the panel. The location of the secondary structure elements of E. coli YdaL is shown above the sequences. Red and blue backgrounds indicate residues whose chemical characteristics are conserved in all and 4 of the 5 species, respectively. Perfectly conserved basic residues are indicated with asterisks. The 100% conserved acidic residues are indicated by asterisks.
