Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms

Figure 3

Comparison of CNA frequency at chromosome 3 between lung SqCC exposed and nonexposed to iAs. The figure represents a comparison of CNA frequency at chromosome 3 generated from 52 lung SqCC biopsies by using a submegabase resolution tiling-set rearray (SMRTr) platform. Of those, 22 derived from arsenic-exposed smokers and never smokers patients from Northern Chile (red) and 30 were current and ex-smokers North American patients without known arsenic exposure nonexposed (blue). Frequency of alteration results for exposed and nonexposed SqCCs cases has been overlaid in this figure, with regions in yellow, denoting a sector of overlapping alteration status in both groups. The magnitude of red, yellow and blue bars represents percentage of samples exhibiting corresponding alteration (0–100%, with blue vertical lines representing 50% frequency). DNA gains and losses are represented to the right and left of chromosome, respectively. Adapted from Martinez et al. [115].