Molecular Biology International / 2012 / Article / Tab 2 / Review Article
TRIM22: A Diverse and Dynamic Antiviral Protein Table 2 Summary of factors that alter TRIM22 expression.
Stimulation Change Tissue Reference Cytokines IFN-α increase CEM, Jurkat, and THP-1 cells [26 ] IFN-α increase H9 cells [47 ] IFN-α increase HepG2 cells [13 ] IFN-α increase Primary MDM [24 ] IFN-α increase U937 [25 ] IFN-α increase U-937-4 cells [46 ] IFN-α /β increase Daudi, and HeLa cells [45 ] IFN-β increase HOS cells [14 ] IFN-γ increase HeLa cells [30 , 45 ] IFN-γ increase HepG2 cells [13 , 48 , 49 ] IFN-γ increase MCF7 cells [30 ] IL-1-β increase Coronary artery endothelium [58 ] IL-2 increase CD4+, CD8+, NK cells [50 ] IL-15 increase CD4+, CD8+, NK cells [50 ] Progesterone increase ABC28, and T47D cells [30 ] TNF-α increase Coronary artery endothelium [58 ] Antigens/Infections EBV infection1 increase BL41-EBV cells1 [55 ] EBV LMP-1 increase DG75 cells [55 ] Hepatitis B virus infection2 increase Liver tissue2 [51 ] Hepatitis C virus infection2 increase Liver tissue2 [52 ] Hepatitis C virus infection increase Liver tissue [53 ] HIV-1 infection increase Immature DC [55 ] HIV-1 infection increase Primary MDM [24 ] HIV-1 infection increase Primary PBMCs [26 ] HIV-1 Tat increase Immature DC [55 ] HPV infection decrease Human keratinocytes [56 ] KSHV infection increase KSHV lesion [57 ] KSHV LANA increase BJAB cells [57 ] LPS increase Primary MDM [24 ] Rubella virus infection increase ECV304 cells [54 ] Activation/Differentiation/Cell Cycle 1α ,25-dihydroxyvitamine D33 increase Primary MDM [24 ] Anti-CD2 increase Primary T cells [47 ] Anti-CD2/CD28 decrease Primary T cells [47 ] Anti-CD2/CD28/CD3 decrease CD4+, CD8+, NK cells4 [50 ] All-trans retinoic acid increase HL60 and NB4 cells [46 ] All-trans retinoic acid increase Primary MDM [24 ] p53 increase K562 and U-937-4 cells5 [46 ] p73 increase U-937-4 cells [46 ] Pioglitazone increase Primary MDM [24 ] UV-irradiation6 increase MCF-7 cells [46 ] Disease SLE decrease CD4+ T cells from SLE patient [59 ] Wilms tumor decrease Tumor tissue [60 , 61 ]
1 BL41 cells that are latently infected with EBV.2 From infected chimpanzees. 3 Hormonally active form of Vitamin D. 4 Only reached significance in CD8+ cells. 5 Cells lack endogenous p53 but stably express a plasmid encoding p53 under control of a temperature-sensitive promoter. Cells were grown at the permissive temperature (32°C) to induce p53 expression. 6 UV-irradiation induces p53 expression.
