Table 2: Summary of factors that alter TRIM22 expression.

StimulationChangeTissueReference

Cytokines
 IFN-αincreaseCEM, Jurkat, and THP-1 cells[26]
 IFN-αincreaseH9 cells[47]
 IFN-αincreaseHepG2 cells[13]
 IFN-αincreasePrimary MDM[24]
 IFN-αincreaseU937[25]
 IFN-αincreaseU-937-4 cells[46]
 IFN-α/βincreaseDaudi, and HeLa cells[45]
 IFN-βincreaseHOS cells[14]
 IFN-γincreaseHeLa cells[30, 45]
 IFN-γincreaseHepG2 cells[13, 48, 49]
 IFN-γincreaseMCF7 cells[30]
 IL-1-βincreaseCoronary artery endothelium[58]
 IL-2increaseCD4+, CD8+, NK cells[50]
 IL-15increaseCD4+, CD8+, NK cells[50]
 ProgesteroneincreaseABC28, and T47D cells[30]
 TNF-αincreaseCoronary artery endothelium[58]

Antigens/Infections
 EBV infection1increaseBL41-EBV cells1[55]
 EBV LMP-1increaseDG75 cells[55]
 Hepatitis B virus infection2increaseLiver tissue2[51]
 Hepatitis C virus infection2increaseLiver tissue2[52]
 Hepatitis C virus infectionincreaseLiver tissue[53]
 HIV-1 infectionincreaseImmature DC[55]
 HIV-1 infectionincreasePrimary MDM[24]
 HIV-1 infectionincreasePrimary PBMCs[26]
 HIV-1 TatincreaseImmature DC[55]
 HPV infectiondecreaseHuman keratinocytes[56]
 KSHV infectionincreaseKSHV lesion[57]
 KSHV LANAincreaseBJAB cells[57]
 LPSincreasePrimary MDM[24]
 Rubella virus infectionincreaseECV304 cells[54]

Activation/Differentiation/Cell Cycle
 1α,25-dihydroxyvitamine D33increasePrimary MDM[24]
 Anti-CD2increasePrimary T cells[47]
 Anti-CD2/CD28decreasePrimary T cells[47]
 Anti-CD2/CD28/CD3decreaseCD4+, CD8+, NK cells4[50]
 All-trans retinoic acidincreaseHL60 and NB4 cells[46]
 All-trans retinoic acidincreasePrimary MDM[24]
 p53increaseK562 and U-937-4 cells5[46]
 p73increaseU-937-4 cells[46]
 PioglitazoneincreasePrimary MDM[24]
 UV-irradiation6increaseMCF-7 cells[46]

Disease
 SLEdecreaseCD4+ T cells from SLE patient[59]
 Wilms tumordecreaseTumor tissue[60, 61]

1BL41 cells that are latently infected with EBV.
2From infected chimpanzees.
3Hormonally active form of Vitamin D.
4Only reached significance in CD8+ cells.
5Cells lack endogenous p53 but stably express a plasmid encoding p53 under control of a temperature-sensitive promoter. Cells were grown at the permissive temperature (32°C) to induce p53 expression.
6UV-irradiation induces p53 expression.