Table 2: Summary of factors that alter TRIM22 expression.

Stimulation Change Tissue Reference Cytokines  IFN-α increase CEM, Jurkat, and THP-1 cells [26]  IFN-α increase H9 cells [47]  IFN-α increase HepG2 cells [13]  IFN-α increase Primary MDM [24]  IFN-α increase U937 [25]  IFN-α increase U-937-4 cells [46]  IFN-α/β increase Daudi, and HeLa cells [45]  IFN-β increase HOS cells [14]  IFN-γ increase HeLa cells [30, 45]  IFN-γ increase HepG2 cells [13, 48, 49]  IFN-γ increase MCF7 cells [30]  IL-1-β increase Coronary artery endothelium [58]  IL-2 increase CD4+, CD8+, NK cells [50]  IL-15 increase CD4+, CD8+, NK cells [50]  Progesterone increase ABC28, and T47D cells [30]  TNF-α increase Coronary artery endothelium [58] Antigens/Infections  EBV infection1 increase BL41-EBV cells1 [55]  EBV LMP-1 increase DG75 cells [55]  Hepatitis B virus infection2 increase Liver tissue2 [51]  Hepatitis C virus infection2 increase Liver tissue2 [52]  Hepatitis C virus infection increase Liver tissue [53]  HIV-1 infection increase Immature DC [55]  HIV-1 infection increase Primary MDM [24]  HIV-1 infection increase Primary PBMCs [26]  HIV-1 Tat increase Immature DC [55]  HPV infection decrease Human keratinocytes [56]  KSHV infection increase KSHV lesion [57]  KSHV LANA increase BJAB cells [57]  LPS increase Primary MDM [24]  Rubella virus infection increase ECV304 cells [54] Activation/Differentiation/Cell Cycle  1α,25-dihydroxyvitamine D33 increase Primary MDM [24]  Anti-CD2 increase Primary T cells [47]  Anti-CD2/CD28 decrease Primary T cells [47]  Anti-CD2/CD28/CD3 decrease CD4+, CD8+, NK cells4 [50]  All-trans retinoic acid increase HL60 and NB4 cells [46]  All-trans retinoic acid increase Primary MDM [24]  p53 increase K562 and U-937-4 cells5 [46]  p73 increase U-937-4 cells [46]  Pioglitazone increase Primary MDM [24]  UV-irradiation6 increase MCF-7 cells [46] Disease  SLE decrease CD4+ T cells from SLE patient [59]  Wilms tumor decrease Tumor tissue [60, 61]

1BL41 cells that are latently infected with EBV. 2From infected chimpanzees. 3Hormonally active form of Vitamin D. 4Only reached significance in CD8+ cells. 5Cells lack endogenous p53 but stably express a plasmid encoding p53 under control of a temperature-sensitive promoter. Cells were grown at the permissive temperature (32°C) to induce p53 expression. 6UV-irradiation induces p53 expression.