Schematic of RASSF1A with location of identified polymorphisms. Location of identified RASSF1A polymorphisms is indicated with respect to amino acid location, changed amino acid, and exon location. A potential binding sequence to an SH3 domain has been identified with a PxxP motif. The ATM phosphorylation site is underlined with surrounding residues shown. The docking sites for several RASSF1A effector proteins are shown including the location of potential D- and KEN-boxes for protein association (D1 to D6). The latter boxes are thought to be important for associations with APC/cdc-20 [12]. The Ras association domain (RA) is present in RASSF1A but has not been convincingly demonstrated to associate with the Ras family of oncogenes [10]. The SARAH domain modulates heterotypic associations with the sterile-20-like kinases, MST1 and MST2 (adapted from El-Kalla et al. (2010)) [13] and Gordon and Baksh (2011) [10].
