Three-Dimensional Molecular Modeling of a Diverse Range of SC Clan Serine Proteases

Figure 2

Multiple amino acid sequence alignment of SC serine proteases. ClustalW was used to align amino acid sequences of SC serine proteases for which their structures were determined experimentally or predicted computationally (highlighted in yellow). Wheat serine carboxypeptidase 2 (CBP2, highlighted in magenta) is used as a standard reference for residue numbering. Only the regions showing the conserved catalytic residues Ser (S), Asp (D), and His (H) are shown (highlighted in blue). Other residues showing medium (•) conservation are highlighted in gray.