HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

<table>Mechanism of action of TDRTIs. The RT is represented as a pale green circle with the priming binding site in cyan (P) and the nucleotide binding site in white (N). The RNA template is shown in blue and the (−)strand DNA in purple. The TDRTI triphosphate (strong green) can be used as RT substrate (1) and is incorporated in the nucleic acid (2). The incorporated TDRTI blocks the further DNA synthesis since the enzyme is not able to efficiently translocate (3).</table>

Molecular Biology International

fig10

Figure 10

Figure 10: HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions 

Figure 10 | HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions 