HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

<table>Mechanism of action of DCTRTIs. The RT is represented as a pale green circle with the priming binding site in cyan (P) and the nucleotide binding site in white (N). The RNA template is shown in blue and the (−)strand DNA in purple. DCTRTI triphosphate (strong green) is incorporated into the growing DNA chain (1). After further nucleotides addition, its presence blocks DNA elongation, probably through steric hindrance interference (yellow) between the RNA:DNA hybrid and the RT nucleic-acid-binding cleft (2). In addition, their incorporation can also block the synthesis of the (+)strand DNA affecting the base pairing (3).</table>

Molecular Biology International

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Figure 11

Figure 11: HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions 

Figure 11 | HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions 