HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

<table>Mechanism of action of RT inhibitors acting as chain terminators. The RT is represented as a pale green circle with the priming binding site in cyan (P) and the nucleotide binding site in white (N).  The RNA template is showed in blue and the (−)strand DNA in purple. The NRTI triphosphate (strong green) (1) competes for the binding with the natural dNTPs, it is incorporated into the growing DNA (2) and it blocks the further DNA elongation because it lacks the 3′-hydroxyl group (3).</table>

Molecular Biology International

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Figure 5

Figure 5: HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions 

Figure 5 | HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions 