Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation Process

Table 1

FDA approved protease inhibitors. Key protease resistance mutations sourced from the 2011 data review of HIV drug resistance by the international AIDS society USA [23].

Protease inhibitor	Year of FDA approval	Key resistance mutations
Saquinavir	1995	G48V, L90M
Ritonavir	1996	Used for boosting
Indinavir	1996	M46I/L, V82A/F/T, I84V
Nelfinavir	1997	D30N, L90M
Fosamprenavir	1999	I50V, I84V
Lopinavir	2000	V32I, I47V/A, L76V, V82A/F/T/S
Atazanavir	2003	I50L, I84V, N88S
Tipranavir	2005	I47V, Q58E, T74P, V82L/T, N83, I84V
Darunavir	2006	I47V, I50V, I54M/L, V76V, I84V