Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy
Figure 4
Loss of RASSF2 decreases cell adhesion and enhances invasion. (a) The H441 control cells and those stably knocked down for RASSF2 were assayed for adhesion as described in Section 2. *Statistically different () from control cells. (b) The cells were assayed for their ability to invade a collagen matrix as described in Section 2. A statistically larger number of cells () that were stably knocked down for RASSF2 were able to migrate through the collagen compared to control cells, indicating that loss of RASSF2 enhances cell invasion.
