Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

Figure 4

Cartoon representation of the LEDGIN 3 (yellow) superimposed with the LEDGF/p75 IBD (gray) in the pocket at the interface of the IN CCD dimer (light blue and orange). LEDGINs bind to the LEDGF/p75 binding pocket in HIV-1 IN and thereby block the interaction of the IBD of LEDGF/p75 with the dimer of the CCD, thereby interfering with tethering of the HIV-1 PIC to the host cell chromatin.