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| A3 Family member | Correlation reported | Identification of cohort | Reference |
|
| A3B | Homozygous deletion of gene associated with higher: rates of HIV infection after exposure, viral set point, and rate of disease progression | 4216 HIV+ patients pooled from 5 longitudinal cohorts: ALIVE, MACS, SFCC, HGDS and MHCS [73] (US-based studies) | An et al. [74] |
|
| A3F and A3G | Level of detectable proviral hypermutations that exhibited A3F/A3G cytidine deaminase signatures associated with higher CD4+ cell count | 215 HIV+ female commercial sex workers plus 25 HIV+ women who were infected perinatally (Nairobi, Kenya) | Land et al. [75] |
|
| A3F and A3G | Elevated expression of A3F and A3G in PBMCs associated with establishment of lower viral set point | 30 women from a well-established [76] cohort of female commercial sex workers (Dakar, Senegal) | Ulenga et al. [77] |
|
| A3G | 186R polymorphism in African Americans associated with rapid progression to AIDS | 2430 HIV+ patients pooled from 5 longitudinal cohorts: ALIVE, MACS, SFCC, HGDS and MHCS [73] (US-based studies) | An et al. [78] |
|
| A3G | Elevated expression of A3G in CD14+ cells associated with resistance to HIV-1 infection after exposure | 30 HESN individuals (Florence, Italy) | Biasin et al. [79] |
|
| A3G | Elevated expression levels inversely associated with viral load in LTNPs | 6 uninfected volunteers; 17 HIV+ progressors; 8 HIV+ LTNPs | Jin et al. [80] |
|
| A3G | C40693T polymorphism, located within intronic sequences, associated with increased risk of infection | 122 HIV-exposed individuals; 69 sero converted after exposure, 53 retained seronegative status (Montreal, Canada) | Valcke et al. [73] |
|
| A3G | HESN individuals expressed elevated levels of A3G when compared to healthy controls; elevated levels of A3G associated with higher CD4+ cell count in HIV+ patients | 26 healthy controls, 37 HESN individuals, 45 HIV+ patients (Mexico City, Mexico) | Vázquez-Pérez et al. [81] |
|
| A3H | Haplotype I associated with protection from HIV-1 infection | 70 serodiscordant couples (Florence, Italy) | Cagliani et al. [59] |
|
