Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications
Figure 2
This image shows determination of HER2 status in 4 samples of breast tumor tissue. Samples (a) and (b) were analyzed by immunohistochemistry (IHC), while samples (c) and (d) were analyzed by fluorescence in situ hybridization (FISH). IHC detects protein and shows an increased expression of HER2 receptors, while FISH detects gene amplification. Sample (a) shows normal levels of HER2 protein expression, and sample (c) shows normal copy numbers of HER2 genes, while samples (b) and (d) show abnormal levels, respectively.
