Ischemic stroke is one of the most common causes of death worldwide
and is most often caused by thrombotic processes. We investigated the changes in
hsCRP and homocysteine levels, two of these risk factors, during the acute period
of ischemic stroke and evaluated the relationship between these levels and
the short-term prognosis. HsCRP and homocysteine levels were measured at
the 2nd, 5th, and 10th days in forty patients admitted within second of an ischemic
stroke. The clinical status of the patients
was simultaneously evaluated with the Scandinavian stroke scale. The results were
compared with 40 healthy control subjects whose age and sex were matched with
the patients. The mean hsCRP levels of the patients were 9.4±7.0 mg/L on the 2nd day, 11.0±7.4 mg/L on the 5th day, and 9.2±7.0 mg/L on the 10th day. The mean hsCRP level of the control
subjects was 1.7±2.9 mg/L. The mean hsCRP levels of the patients on the 2nd, 5th, and 10th
days were significantly
higher than the control subjects (P<.001).
The patients' mean homocysteine levels were 40.6±9.6μmol/L on the 2nd day, 21.7±11.1μmol/L on the 5th day, and 20.7±9.2μmol/L on the 10th day. The mean homocysteine level of the control
subjects was 11.2±1.1μmol/L. The homocysteine levels of the patients were higher than
the control subjects at all
times (P<.01). In conclusion, patients with stroke have a higher circulating serum
hsCRP and homocysteine levels. Short-term unfavorable prognosis seems
to be associated with
elevated serum hsCRP levels in patients with stroke. Although serum
homocysteine was found to be higher, homocysteine seems not related
to prog nosis.