The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP

Xiping, Zhang; Hua, Tian; Hanqing, Chen; Li, Chen; Zhiwei, Wang; Keyi, Wang; Wei, Yan; Yun, Li; Qingyu, Li; Qing, He; Fei, Wang

doi:https://doi.org/10.1155/2007/19469

Mediators of Inflammation

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Research Article | Open Access

Volume 2007 | Article ID 019469 | https://doi.org/10.1155/2007/19469

The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP

Zhang Xiping,¹Tian Hua,²Chen Hanqing,³Chen Li,²Wang Zhiwei,⁴Wang Keyi,⁴Yan Wei,⁵Li Yun,⁵Li Qingyu,⁵He Qing,⁵and Wang Fei⁵

Received04 Aug 2007

Accepted24 Oct 2007

Published17 Dec 2007

Abstract

Purpose. To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP). Methods. The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The contents of some inflammatory indexes in blood were determined. The rat mortality, pathological changes of heart, the changes of NF-κB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels as well as apoptotic index were observed in all groups, respectively, at 3 hours, 6 hours, and 12 hours after operation. Results. The survival rate of model group was less than treated groups at 12 hours, difference was significant. The contents of some inflammatory indexes of the treated groups were lower than those of the model group to various degrees at different time points. The pathological myocardial changes under light microscope were milder in treated groups than in model group. The changes of NF-κB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in all groups were different. There was only a case of myocardial cell apoptosis in an Octreotide-treated group at 6 hours. Conclusion. Baicalin and Octreotide have protecting effects on heart injury of rats with SAP.

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Copyright © 2007 Zhang Xiping et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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