Angiogenic Factor Expression in Hepatic Cirrhosis

Giatromanolaki, Alexandra; Kotsiou, Stamatia; Koukourakis, Michael I.; Sivridis, Efthimios

doi:https://doi.org/10.1155/2007/67187

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 067187 | https://doi.org/10.1155/2007/67187

Angiogenic Factor Expression in Hepatic Cirrhosis

Alexandra Giatromanolaki,¹Stamatia Kotsiou,²Michael I. Koukourakis,³and Efthimios Sivridis¹

Received14 Oct 2006

Revised12 Dec 2006

Accepted12 Dec 2006

Published08 Feb 2007

Abstract

The pathogenesis of fibrosis in hepatic cirrhosis remains obscure. This study examines the eventual role of angiogenic factors in the fibrotic process. A series of 55 cirrhotic livers was studied for the proliferation state of fibroblasts, and the expression of vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and the basic and acidic fibroblast growth factor (bFGF, aFGF) in both fibroblasts and hepatic cells. The angiogenic and/or fibrogenic factors VEGF, TP, bFGF, and aFGF were clearly expressed in regenerative hepatocytes, but not in fibroblasts of diffuse hepatic fibrosis. The immunohistochemical findings suggest that angiogenic factors and factors promoting oxidative stress (i.e., TP) produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis.

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Copyright

Copyright © 2007 Alexandra Giatromanolaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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