Increased Responsiveness to Toll-Like Receptor 4 Stimulation in Peripheral Blood Mononuclear Cells from Patients with Recent Onset Rheumatoid Arthritis

Table 3

Spontaneous and stimulated TNFα production by peripheral blood mononuclear cells from patients with rheumatoid arthritis (RA), osteoarthrosis (OA), and healthy control (HC); 𝑃<.05^∗—significantly different from nonstimulated; #—significant difference between RA and HC ∧—significant difference between RA and OA.

	Nonstimulated	LPS 1 ng/mL	LPS 10 ng/mL	LPS 100 ng/mL	BGN 0,1 ng/mL	BGN 1 ng/mL	BGN 10 ng/mL
Group of subjects	Concentration of TNFα (ng/mL)
RA	0,05⋀#	0,72⋀#	2,02∗	2,84∗	0,1⋀#	0,26	0,07⋀#
OA	0,59	4,71∗	2,48∗	2,62∗	0,84	0,45	0,71
HC	0,49	2,59∗	1,98∗	1,94∗	0,63	0,65	0,68∗