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Linked References

1. American Cancer Society, Overview: Ovarian Cancer 2006, American Cancer Society, New York, NY, USA, 2006.
2. R. Yancik, L. G. Ries, and J. W. Yates, “Ovarian cancer in the elderly: an analysis of surveillance, epidemiology, and end results program data,” American Journal of Obstetrics and Gynecology, vol. 154, no. 3, pp. 639–647, 1986.
3. E. F. C. Murta, C. S. Da Silva, R. A. S. Gomes, B. M. Tavares-Murta, and A. L. K. O. Melo, “Ultrasonographic criteria and tumor marker assay are good procedures for the diagnosis of ovarian neoplasia in preselected outpatients,” European Journal of Gynaecological Oncology, vol. 25, no. 6, pp. 707–712, 2004.
4. L. A. Padilla, D. M. Radosevich, and M. P. Milad, “Limitations of the pelvic examination for evaluation of the female pelvic organs,” International Journal of Gynecology & Obstetrics, vol. 88, no. 1, pp. 84–88, 2005. View at Publisher · View at Google Scholar · View at PubMed
5. E. F. C. Murta and R. S. Nomelini, “Early diagnosis and predictors of malignancy of adnexal masses,” Current Opinion in Obstetrics & Gynecology, vol. 18, no. 1, pp. 14–19, 2006. View at Publisher · View at Google Scholar · View at PubMed
6. S. Moncada, R. M. J. Palmer, and E. A. Higgs, “Nitric oxide: physiology, pathophysiology, and pharmacology,” Pharmacological Reviews, vol. 43, no. 2, pp. 109–142, 1991.
7. L. Li, R. G. Kilbourn, J. Adams, and I. J. Fidler, “Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells,” Cancer Research, vol. 51, no. 10, pp. 2531–2535, 1991.
8. D. Fukumura, S. Kashiwagi, and R. K. Jain, “The role of nitric oxide in tumour progression,” Nature Reviews Cancer, vol. 6, no. 7, pp. 521–534, 2006. View at Publisher · View at Google Scholar · View at PubMed
9. L. A. Ridnour, D. D. Thomas, S. Donzelli, et al., “The biphasic nature of nitric oxide responses in tumor biology,” Antioxidants & Redox Signaling, vol. 8, no. 7-8, pp. 1329–1337, 2006. View at Publisher · View at Google Scholar · View at PubMed
10. V. J. S. Chhatwal, S. M. Moochhala, S. T. F. Chan, and S. S. Ngoi, “Nitric oxide and cancer,” Medical Hypotheses, vol. 46, no. 1, pp. 21–24, 1996. View at Publisher · View at Google Scholar
11. T. Akaike and H. Maeda, “Nitric oxide and virus infection,” Immunology, vol. 101, no. 3, pp. 300–308, 2000. View at Publisher · View at Google Scholar
12. J. Rieder, C. Marth, G. Totzke, M. Smolny, M. Seibel, and G. Hoffmann, “Different patterns of inducible nitric oxide synthase gene expression in ovarian carcinoma cell lines,” Anticancer Research, vol. 20, no. 5, pp. 3251–3258, 2000.
13. H. Ohshima and H. Bartsch, “Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 305, no. 2, pp. 253–264, 1994. View at Publisher · View at Google Scholar
14. Q. Shi, Q. Xiong, B. Wang, X. Le, N. A. Khan, and K. Xie, “Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis,” Cancer Research, vol. 60, no. 10, pp. 2579–2583, 2000.
15. S. P. Andrade, I. R. Hart, and P. J. Piper, “Inhibitors of nitric oxide synthase selectively reduce flow in tumour-associated neovasculature,” British Journal of Pharmacology, vol. 107, no. 4, pp. 1092–1095, 1992.
16. S. C. Chu, J. Marks-Konczalik, H.-P. Wu, T. C. Banks, and J. Moss, “Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters,” Biochemical and Biophysical Research Communications, vol. 248, no. 3, pp. 871–878, 1998. View at Publisher · View at Google Scholar · View at PubMed
17. S. F. Serov, R. E. Scully, and L. H. Sobin, Histological Typing of Ovarian Tumours, vol. 9 of International Histological Classification of Tumours, World Health Organization, Geneva, Switzerland, 1973.
18. International Federation of Gynecology and Obstetrics (FIGO), “Classification and staging of malignant tumors in the female pelvis,” Acta Obstetricia et Gynecologica Scandinavica, vol. 50, pp. 1–7, 1971.
19. B. M. Tavares Murta, F. De Queiróz Cunha, R. Miranda, S. J. Adad, and E. F. Candido Murta, “Differential tumor microenvironment in human ovarian cystic tumors,” Tumori, vol. 90, no. 5, pp. 491–497, 2004.
20. H. H. H. W. Schmidt, P. Wilke, B. Evers, and E. Böhme, “Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol,” Biochemical and Biophysical Research Communications, vol. 165, no. 1, pp. 284–291, 1989. View at Publisher · View at Google Scholar
21. L. C. Green, K. Ruiz de Luzuriaga, D. A. Wagner, et al., “Nitrate biosynthesis in man,” Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 12, pp. 7764–7768, 1981.
22. E. Özel, H. E. Peştereli, T. Şimşek, G. Erdoğan, and F. Ş. Karaveli, “Expression of cyclooxygenase-2 and inducible nitric oxide synthase in ovarian surface epithelial carcinomas: is there any correlation with angiogenesis or clinicopathologic parameters?” International Journal of Gynecological Cancer, vol. 16, no. 2, pp. 549–555, 2006. View at Publisher · View at Google Scholar · View at PubMed
23. L. L. Thomsen, F. G. Lawton, R. G. Knowles, J. E. Beesley, V. Riveros-Moreno, and S. Moncada, “Nitric oxide synthase activity in human gynecological cancer,” Cancer Research, vol. 54, no. 5, pp. 1352–1354, 1994.
24. A. H. Klimp, H. Hollema, C. Kempinga, A. G. J. van der Zee, E. G. E. de Vries, and T. Daemen, “Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages,” Cancer Research, vol. 61, no. 19, pp. 7305–7309, 2001.
25. L. L. Thomsen, D. W. Miles, L. Happerfield, L. G. Bobrow, R. G. Knowles, and S. Moncada, “Nitric oxide synthase activity in human breast cancer,” British Journal of Cancer, vol. 72, no. 1, pp. 41–44, 1995.
26. C. S. Cobbs, J. E. Brenman, K. D. Aldape, D. S. Bredt, and M. A. Israel, “Expression of nitric oxide synthase in human central nervous system tumors,” Cancer Research, vol. 55, no. 4, pp. 727–730, 1995.
27. M. Jaiswal, N. F. Larusso, and G. J. Gores, “Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis,” American Journal of Physiology, vol. 281, no. 3, pp. G626–G634, 2001.
28. F. Cianchi, C. Cortesini, O. Fantappiè, et al., “Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis,” American Journal of Pathology, vol. 162, no. 3, pp. 793–801, 2003.
29. M. Ichinoe, T. Mikami, H. Shiraishi, and I. Okayasu, “High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas,” Histopathology, vol. 45, no. 6, pp. 612–618, 2004. View at Publisher · View at Google Scholar · View at PubMed
30. W. Li, R.-J. Xu, L.-H. Jiang, J. Shi, X. Long, and B. Fan, “Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma,” Medical Oncology, vol. 22, no. 1, pp. 63–70, 2005. View at Publisher · View at Google Scholar · View at PubMed
31. Q.-S. Ng, V. Goh, J. Milner, et al., “Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study,” The Lancet Oncology, vol. 8, no. 2, pp. 111–118, 2007. View at Publisher · View at Google Scholar · View at PubMed
32. J. M. Malone, G. M. Saed, M. P. Diamond, R. J. Sokol, and A. R. Munkarah, “The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer,” American Journal of Obstetrics and Gynecology, vol. 194, no. 4, pp. 1110–1116, 2006. View at Publisher · View at Google Scholar · View at PubMed
33. M. A. Anttila, K. Voutilainen, S. Merivalo, S. Saarikoski, and V.-M. Kosma, “Prognostic significance of iNOS in epithelial ovarian cancer,” Gynecologic Oncology, vol. 105, no. 1, pp. 97–103, 2007. View at Publisher · View at Google Scholar · View at PubMed
34. K. Xie, Z. Dong, and I. J. Fidler, “Activation of nitric oxide synthase gene for inhibition of cancer metastasis,” Journal of Leukocyte Biology, vol. 59, no. 6, pp. 797–803, 1996.
35. M. R. Raspollini, G. Amunni, A. Villanucci, et al., “Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome,” Gynecologic Oncology, vol. 92, no. 3, pp. 806–812, 2004. View at Publisher · View at Google Scholar · View at PubMed
36. L. L. Thomsen, J. M. Sargent, C. J. Williamson, and A. W. Elgie, “Nitric oxide synthase activity in fresh cells from ovarian tumour tissue: relationship of enzyme activity with clinical parameters of patients with ovarian cancer,” Biochemical Pharmacology, vol. 56, no. 10, pp. 1365–1370, 1998. View at Publisher · View at Google Scholar
37. P. A. Sherman, V. E. Laubach, B. R. Reep, and E. R. Wood, “Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line,” Biochemistry, vol. 32, no. 43, pp. 11600–11605, 1993. View at Publisher · View at Google Scholar
38. A. Heller, “Apoptosis-inducing high $\cdot \text{NO}$ concentrations are not sustained either in nascent or in developed cancers,” ChemMedChem, vol. 3, no. 10, pp. 1493–1499, 2008. View at Publisher · View at Google Scholar · View at PubMed
39. K. Xie and I. J. Fidler, “Therapy of cancer metastasis by activation of the inducible nitric oxide synthase,” Cancer and Metastasis Reviews, vol. 17, no. 1, pp. 55–75, 1998. View at Publisher · View at Google Scholar
40. K. Engels, S. K. Knauer, S. Loibl, et al., “NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas,” Cancer Research, vol. 68, no. 13, pp. 5159–5166, 2008. View at Publisher · View at Google Scholar · View at PubMed