Mediators of Inflammation
Volume 2008 (2008), Article ID 285989, 6 pages
doi:10.1155/2008/285989
Research Article

The Assessment of Autoimmunological Status and Prevalence of Different Forms of Celiac Disease among Children with Type 1 Diabetes Mellitus and Celiac Disease

Grazyna Deja,1 Anna Myrda,2 Przemyslawa Jarosz-Chobot,1 and Urszula Siekiera3

1Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, Katowice 40-752 , Poland
2Schwarzwald-Baar Klinikum, 78011 Villingen-Schwenningen, Germany
3Blood Center, 40-074 Katowice, Poland

Received 5 August 2007; Accepted 3 January 2008

Academic Editor: Freek J. Zijlstra

Copyright © 2008 Grazyna Deja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r=‐0.35, p<.05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset.