COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study

Table 1

Association of combined COX-2 genotypes with coronary atherosclerotic changes, number of main coronary arteries with stenosis of over 50%, and myocardial infarction.

	Genotype
	GG	GC + CC	P value^*	P value^†
All subjects	n = 223	n = 77	n = 300	n = 118
Atherosclerotic changes (%)
Fatty streaks	9.91±0.54	8.69±0.74	0.161	0.341
Fibrous plaques	5.79±0.41	6.31±0.72	0.858	0.567
Calcifications	3.78±0.39	5.37±1.01	0.120	0.031
Complicated lesions	2.24±0.37	4.15±1.25	0.024	0.017
Number of coronary arteries with stenosis of over 50% (0–3)	0.33±0.67	0.58±0.93	0.036	0.008
Myocardial infarction	23.3%	26.0%	0.809	0.350
Subjects with coronary event	n = 52	n = 20	n = 72	n = 35
Complicated lesions	6.81±8.67	14.00±18.84	0.040	0.015
Number of coronary arteries with stenosis of over 50% (0–3)	1.00±1.00	1.69±1.14	0.040	0.050
Subjects with no coronary event	n = 172	n = 56	n = 228	n = 83
Complicated lesions	0.91±2.85	0.88±1.55	0.876	0.541
Number of coronary arteries with stenosis of over 50% (0–3)	0.18±0.46	0.20±0.40	0.884	0.990

Mean ± SE. ANCOVA ^* adjusted by age and BMI, or ^† age, BMI, smoking, hypertension and diabetes.