Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells: Evidence of an Oxidant-Sensitive Pathway
Figure 1
Effects of captopril (CPT,
(a) and (b)), zofenoprilat (ZOF,
(a) and (c)), lisinopril (LIS,
(a) and (d)), enalaprilat (ENA,
(a) and (e)) and bradykinin (BK,
(a) and (f)) on endothelin-1 secretion (expressed as % of control) by vascular
endothelial cells derived from umbilical cord vein after 8 hours of incubation
both alone and in the presence of either ,
that is, a bradykinin receptor antagonist (B1ra, ), or ,
that is, a bradykinin receptor antagonist (B2ra, ), or the NO synthase competitive inhibitor
-nitro-L-arginine methyl ester (L-NA, ). (A)
or less versus CPT,
ZOF, LIS, ENA, and BK; (B) or less versus ZOF; (C)
or less versus CPT+B1ra; (D) or less versus ZOF+B1ra,
ZOF+B2ra, and ZOF+L-NA; (E) versus ZOF+B1ra; (F)
versus LIS+B1ra; (G) or less versus ENA+B1ra; (H)
versus BK+B1ra.
